Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie
 

Canvax Biotech


Canvax is a leading manufacturer and supplier of the most innovative solutions, kits and R&D Reagents inside Molecular Biology fields. Since its foundation in 2001, Canvax offers reliable, cost-effective and easy-to-use innovative tools for research.

Based in Córdoba (Spain), since its beginning it has focused on R&D of multiplex high throughput platforms (HTS) for Drug discovery and Diagnostic applied biosensors. Over a decade later, Canvax is a worldwide leading expert in GPCR expression in heterologous cells, with important patents and exclusive know-how. Canvax prides itself to be the first company to get an unprecedented milestone that could revolutionize the Diagnostics sector: Canvax established stable high-level expression of odour GPCRs into heterologous cell lines in 2014.

This key milestone, that could be applied in diagnostic, perfume and cosmetic industry, are being employed to obtain a molecular nose, a sensitive and non-invasive diagnostic molecular device for early detection of cancer, as the nose of trained dogs do. Thanks to this project, Canvax was awarded, in 2013, with the largest Public & Private Contract for Pre competitive Technology Development in Spanish history.

 
> Canvax Biotech > Produkte für die Forschung > Zellbasierte Assay-Kits > Gesundheit der Zellen > Senescence
Senescence

Senescence


Normal primary cells proliferate in culture for a limited number of population doublings before undergoing terminal growth arrest and acquiring a senescence phenotype. This finite life is correlated with the age of the organism and with the life expectancy of the species from which the cells were obtained; so the older the age, the shorter the lifespan, the less the cells can double the population.
Senescent cells are characterized by irreversible G1 growth arrest involving repression of the genes that lead to cell cycle progression and upregulation of cell cycle inhibitors such as p16INK4a, p53 and its transcriptional target, p21CIP1. Senescent cells are resistant to mitogen-induced proliferation and adopt a characteristic flattened morphology. Research on the pathways that positively regulate senescence and the ways in which cells prevent senescence is therefore essential to understanding carcinogenesis. Normal cells have several mechanisms in place to protect against uncontrolled proliferation and tumorigenesis.
Senescent cells show common biochemical markers such as expression of β-galactosidase (SA-β-Gal) activity associated with acid senescence. While senescence has been characterized primarily in cultured cells, there is also evidence that this occurs in vivo. Cells expressing senescence markers such as SA-β-Gal have been identified in normal tissues.

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