DDIT3 probe for ISH CE/IVD - Sarcomas

DDIT3 probe for ISH CE/IVD - Sarcomas

 

Liposarcoma is the most common soft tissue malignancy in adults accounting for at least 20% of all sarcomas in this age group. Liposarcoma is a lipogenic tumour subclassified into four main histologic groups, including well-differentiated liposarcoma (lipoma-like and sclerosing types), myxoid-round cell liposarcoma, pleomorphic liposarcoma, and dedifferentiated liposarcoma. The histologic group is predictive of both the clinical course of the disease and the ultimate prognosis.
Myxoid-round cell liposarcoma is a subtype of liposarcoma characterized by the presence of the reciprocal chromosomal translocation t(12;16)(q13;p11). This translocation creates the FUS-DDIT3 chimeric gene.
The DDIT3 gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis.

 

 

Ergebnis Ihrer Suche : 4 Produkt(e) gefunden

Grenzen Sie Ihre Suche ein :

RUOCE / IVD
  • Green-Orange 2
  • DIG-DNP 1
  • Probe
  • ISH 4
FILTER ANWENDEN
REINITIALISIEREN


Katalog-Nummer
Beschreibung
Cond.
Preis zzgl. MwSt.
C-3047-100
 0,1ml/10tests