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RUNX1 probe for FISH CE/IVD - Acute myeloid leukemia (AML)
The balanced chromosomal translocation t(8;21) is found in about 90% of acute myeloid leukemia (AML) patients. AML is a heterogeneous clonal disorder of hematopoietic progenitor cells and one of the most common malignant myeloid disorders in adults. The runt related transcription factor 1 gene (RUNX1) and RUNX1 translocation partner 1 (RUNX1T1) gene are both involved in the transcriptional regulation of genes during normal hematopoiesis. The non-random translocation t(8;21) (q21.3;q22.1) is strongly associated with the French-American-British (FAB) phenotype M2 (AML-M2) and produces a chimeric gene consisting of the 5‘-region of the RUNX1 gene fused to the 3‘-region of the RUNX1T1 gene. The chimeric protein is thought to be associated with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Fluorescence in situ Hybridization (FISH) can provide important information for the management of patients with hematologic disorders.
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RUOCE / IVD
- Green-Orange 2
- Orange-Green 2
- Probe
- ISH 6
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