Matrix Metalloproteinases
The extracellular matrix (ECM) is the extracellular part of animal tissue that usually provides structural support to the animal cells in addition to performing various other important functions.
Formation of the extracellular matrix is essential for processes like growth, wound healing and fibrosis. An understanding of ECM structure and composition also helps in comprehending the complex dynamics of tumor invasion and metastasis in cancer biology as metastasis often involves the destruction of extracellular matrix by enzymes such as serine and Threonine proteases and Matrix metalloproteinase.CMG1, CO4A2, Hyaluronan synthase, Laminin, Laminin B2 , Laminin beta , Laminin gamma , Laminin receptor, Laminin S, Plakophilin, Robo4, SPARC.