Chemical Synthesis of Proteins, Peptides and Antibodies

 

Custom Chemical Protein Peptide and Antibody Synthesis with absolute precision, very high purity and quality

Designing your therapeutic proteins with the highest purity, free from biological contamination, endotoxins, and isoforms.

We rely on an automated molecular assembly platform. Each protein is meticulously assembled amino acid by amino acid, utilizing a completely controlled production chain: a more precise and versatile technology which surpasses the limitations of traditional chemical and biological production methods.

Our innovative technology is based on a unique mastery of 100% automated molecular assembly processes, enabling the production of proteins, amino acid by amino acid.

 

Our mission, vision and values

Develop and accelerate your projects for the production of therapeutic proteins and vaccines.
Making today's and tomorrow's biopharmaceuticals purer and safer.

• EXPERTISE: Our expertise in protein synthesis, cultivated over 20 years, enables us to meet the challenges of design and production for your therapeutic proteins.
• CLIENT FIRST: We listen to your needs to collaboratively build therapeutic proteins which enhance human health.
• RELIABILITY: Over the past 11 years, our lab has dedicated itself to the successful completion of all entrusted projects.
• RESPONSIVENESS: In pharmaceutical projects, changes are frequent, and some are unforeseeable. We adapt to your needs and any changes you may encounter.

We offer pharma and biotech companies services for the design and production of therapeutic proteins.

These services are based on proprietary expertise and an exclusive robotic molecular assembly platform, allowing us to construct tailor-made proteins, amino acid by amino acid.

This platform provides extensive optimization possibilities for proteins in order to maximize their therapeutic potential:

• Production of large proteins with complete structural control.
• Obtention of a protein pure enough for use in human health.
• Design and production of proteins which can't be produced by biological methods (membrane proteins, toxins, etc.).
• Optimization of protein structure to maximize therapeutic efficacy.

We master the protein synthesis process, introducing specific modifications to meet your most demanding needs. Protein creation is a true collaboration. We work hand in hand to design, customize, and optimize your proteins to best suit your requirements.

 

Our protein synthesis process:

We master the protein synthesis process, introducing specific modifications to meet your most demanding needs. Protein creation is a true collaboration. We work hand in hand to design, customize, and optimize your proteins to best suit your requirements.

1. Design – Tailored Proteins: We design the desired protein (fusion, cyclic, post-translational or specific modifications).
2. Protein Synthesis – Automated Synthesis: We synthesize the protein amino acid by amino acid using our innovative and automated technology.
3. Purification – High Purity: We reach high purity without the need for multiple purifications.
4. Folding – Maximizing Biological Activity: We fold the protein if necessary to ensure its biological activity.

 

Optimization of Your Proteins

With our expertise and exclusive technological platform, we design and optimize molecular structures with the aim of making them:

• Purer
• More stable
• More soluble
• Biologically more active

 

Customized Production of Therapeutic Proteins

Our platform is tailored for protein production at all development stages, ranging from research to clinical batch production (GMP).

The automated production methods employed facilitate a smooth and rapid transition to the industrial stage:

• Assembly of proteins amino acid by amino acid
• Complete mastery of the production process
• Reproducibility of processes

 

Therapeutic Domains

Our teams are dedicated to the production of therapeutic molecules for human health.

They have significant experience in various therapeutic areas or specialties:

• Oncology
• Autoimmune diseases
• Infectiology
• Parkinson's disease
• Vaccination

 

We rely on an automated molecular assembly platform. Each protein is assembled amino acid by amino acid, thanks to a fully controlled production chain: a more precise and versatile technology which surpasses the limitations of conventional chemical and biological production methods.

It allows the production of proteins with superior purity, including:

It offers broad possibilities for optimizing proteins in order to maximize their therapeutic potential:

• Lengths up to 400 amino acids
• Native or modified proteins
• Complete control over protein structure
• High purity guaranteed:
  • Without isoforms
  • Without residues
  • Without biological contaminants
  • Without endotoxins

 

Robotic Molecular Assembly

Our innovative technology is based on a unique mastery of 100% automated molecular assembly processes, allowing the production of proteins, amino acid by amino acid.

1. Synthesis of the fragment: Amino acids are pieced together one by one to form the desired fragment.
2. Assembly of fragments: Synthesized fragments are assembled to obtain the desired protein.
3. Obtaining the linear protein.
4. Folding of the protein if necessary. The linear protein is folded to ensure its biological activity.
5. Obtaining the folded protein.

You encounter problems with the production of your proteins?

You need to produce a protein with specific modifications?

You want an optimal protein chemically synthesized in vitro?

Chemical protein synthesis can help you!

 

Advantages

• Protein with maximized biological activity
• Complex proteins that cannot be produced by biological systems
• Very high purity (Endotoxin-Free)
• Bypass the problems with the protein production (purity, inclusion bodies...)
• Animal free
• Homogeneity in Preparations
• Need unnatural amino acids or finely controlled sidechains
• Up to 400 AA (40 kD) long
• Automated production at milligrams scale-up to Industrial scale
• Difficult-to-produce proteins

Thanks to the evolving regulations and advanced technology, we can now think about biosimilar medications free of endotoxins and without other rDNA production contaminants impurities.

 

Please contact us at tech@clinisciences.com for more information or for a quote request.