Molecular Dimensions
Molecular Dimensions ist ein weltweit führender Anbieter von modernen Screens, Reagenzien, anderen Verbrauchsmaterialien und Instrumenten für die Proteinstrukturbestimmung mittels Röntgenkristallografie.
Molecular Dimensions bietet die innovativste Produktpalette aus den neuesten Entwicklungen der strukturbiologischen Forschung. Das Unternehmen hat derzeit über 20 Projekte in verschiedenen Entwicklungsstadien, von neuen Bildschirmen und Reagenzien für die Kristallzüchtung über neue Laborplastikartikel bis hin zu einer Reihe von Instrumenten. Website: www.moleculardimensions.com
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Reducing agent - 2-Mercaptoethanol
2-Mercaptoethanol, also known as β-mercaptoethanol or BME, is a chemical compound with the molecular formula C₂H₆OS. It is a strong reducing agent and is widely used in biological and biochemical applications. Some of its key properties and applications include:
Chemical Properties:
- Thiol (sulfhydryl) group: Highly reactive and capable of donating electrons.
- Reducing properties: Effective in breaking disulfide bonds in proteins.
Biological and Biochemical Applications:
- Protein denaturation and unfolding.
- Cell culture: Reducing agent to protect cells from toxic effects of reactive oxygen species (ROS) .
- RNA and DNA studies: Inhibits ribonucleases and deoxyribonucleases to preserve nucleic acid integrity.
- Polyacrylamide Gel Electrophoresis (PAGE): Denatures proteins and maintains them in a reduced state during electrophoresis.
Safety Considerations:
- Toxic if swallowed, inhaled, or in contact with skin.
- Causes severe eye irritation and may result in corneal injury.
- May cause nausea, headache, dizziness, unconsciousness, and coma when inhaled in high concentrations.
- Prolonged or repeated skin contact may cause defatting and dermatitis.
While 2-mercaptoethanol is a valuable reagent, it should be handled with care due to its strong odor and toxicity. Appropriate protective measures, such as working in a well-ventilated area and using personal protective equipment, should be taken
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