General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospho-Beta-2 adrenergic receptor-Ser355/S356 (331-380 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | ADRB2 |
| Gene ID: | 154 |
| Uniprot ID: | ADRB2_HUMAN |
| Immunogen Region: | 331-380 aa |
| Specificity: | Phospho-AR-Beta 2 (S355/S356) Polyclonal Antibody detects endogenous levels of AR-Beta 2 protein only when phosphorylated at S355/S356. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Adrenergic Receptor B2 around the phosphorylation site of Ser355 and Ser356 at the amino acid range 331-380 |
Description
| Function | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. |
| Protein Name | Beta-2 Adrenergic ReceptorBeta-2 AdrenoreceptorBeta-2 Adrenoceptor |
| Database Links | Reactome: R-HSA-390696Reactome: R-HSA-418555Reactome: R-HSA-5689880Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly EndosomeGolgi ApparatusColocalizes With Vhl At The Cell MembraneActivated Receptors Are Internalized Into Endosomes Prior To Their Degradation In LysosomesActivated Receptors Are Also Detected Within The Golgi Apparatus |
| Alternative Antibody Names | Anti-Beta-2 Adrenergic Receptor antibodyAnti-Beta-2 Adrenoreceptor antibodyAnti-Beta-2 Adrenoceptor antibodyAnti-ADRB2 antibodyAnti-ADRB2R antibodyAnti-B2AR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance