Chloroquine

Biological Activity

Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis.

Product Citations

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  Autophagy. 2024 Jun 6.

  The novel lnc-HZ12 suppresses autophagy degradation of BBC3 by preventing its interactions with HSPA8 to induce trophoblast cell apoptosis
  Chloroquine purchased from AbMole

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  Front Immunol. 2023 Mar 14;14:1120996.

  ROS-AMPK/mTOR-dependent enterocyte autophagy is involved in the regulation of Giardia infection-related tight junction protein and nitric oxide levels
  Chloroquine purchased from AbMole

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  Arch Oral Biol. 2023 Apr 18;151:105700.

  Wrinkled topography regulates osteogenesis via autophagy-mediated Wnt/β-catenin signaling pathway in MC3T3-E1 cells
  Chloroquine purchased from AbMole

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  Journal of Clinical Hepatology. 2023 Sep;p2103-2109.

  Mechanistic studies on the regulation of non-alcoholic fatty liver disease by growth differentiation factor 11
  Chloroquine purchased from AbMole

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  J Clin Hepatol. 2023 Sep;Vol. 39.

  Mechanism of growth differentiation factor 11 regulating nonalcoholic fatty liver disease
  Chloroquine purchased from AbMole

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  Ecotoxicol Environ Saf. 2022 Jun 1;237:113564.

  Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop
  Chloroquine purchased from AbMole

• 

  Adv Sci (Weinh). 2021 Feb.

  Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple‐Negative Breast Cancer Tumor Growth
  Chloroquine purchased from AbMole

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  Life Sci. 2020 Nov 15;261:118484.

  Chloride channel 7 protects from redox status impairment-induced renal tubular epithelial cell apoptosis by activating autophagy
  Chloroquine purchased from AbMole

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  Int J Neurosci. 2020 Mar 11;1-15.

  Autophagy-deficiency in Bone Marrow Mononuclear Cells From Patients With Myasthenia Gravis: A Possible Mechanism of Pathogenesis.
  Chloroquine purchased from AbMole

• 

  Anat Rec (Hoboken). 2020 Jan 21.

  Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
  Chloroquine purchased from AbMole

Chemical Information

Molecular Weight	319.87
Formula	C18H26ClN3
CAS Number	54-05-7
Solubility (25°C)	DMSO ≥ 50 mg/mL
Storage	4°C, protect from light, sealed

References

[1] Paulo Michel Pinheiro Ferreira, et al. Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms

[2] Winnie Fong, et al. Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy

[3] Gricelis P Martinez, et al. The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases

[4] Bruno Mgarbane. Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution

[5] Franck Touret, et al. Of chloroquine and COVID-19