DES Antibody (OABF00394-100UL) : HRP
Katalog-Nummer OABF00394-HRP
Size : 100ul
Marke : Aviva Systems Biology
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Telefonnummer : +1 850 650 7790
DES Antibody (OABF00394)
| Datasheets/Manuals | Printable datasheet for DES Antibody (OABF00394) |
|---|
| Predicted Species Reactivity | Bovine|Chicken|Dog|Guinea Pig|Horse|Human|Mouse|Porcine|Rabbit|Rat|Sheep |
|---|---|
| Product Format | Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | ELISA, FC, ICC, IF, IHC-Fr, IHC-P, WB |
| Additional Information | Subcellular location: Cytoplasm |
| Reconstitution and Storage | -20°C |
| Immunogen | KLH conjugated synthetic peptide derived from human Desmin |
| Purification | Protein A Purified |
| Concentration | 1 ug/ul |
| Application Info | WB: 1:100 - 1000 IHC-P: : 1:100 - 500 |
| Gene Symbol | DES |
|---|---|
| Gene Full Name | desmin |
| Alias Symbols | cardiomyopathy, dilated 1F (autosomal dominant);CDCD3;CSM1;CSM2;desmin;epididymis secretory sperm binding protein;intermediate filament protein;LGMD1D;LGMD1E;LGMD2R. |
| NCBI Gene Id | 1674 |
| Protein Name | Desmin |
| Description of Target | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). |
| Uniprot ID | P17661 |
