Human Metabotropic Glutamate Receptor 4 (GRM4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GRM4
Locus ID	2914
Kit Components	GA101969G1, Metabotropic Glutamate Receptor 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101969G2, Metabotropic Glutamate Receptor 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101969G3, Metabotropic Glutamate Receptor 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000841, NM_001256809, NM_001256810, NM_001256811, NM_001256812, NM_001256813, NM_001256814, NM_001282847, NR_046379
UniProt ID	Q14833
Synonyms	GPRC1D; mGlu4; MGLUR4
Summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]