MIN-6 cells
Katalog-Nummer C0018008
Size : OneFrozenvial
Contact local distributor :
Disease:
Insulinoma (SV40 T-antigen induced cell immortalization) Pancreatic Islets Mus musculus Pancreas β cells Adherent AddexBio-Advanced Medium (C0003-04) + other components critical to the cell growth listed on the datasheet. 1:2 to 1:3 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37°C Culture medium supplemented with 20% (v/v) FBS and 7.5% (v/v) DMSO II Bacteria: Negative Yeast: Negative Mycoplasma: Negative HIV: Negative Hepatitis B: Negative Hepatitis C: Negative Express glucokinase and Glut2. AR-42J cells BxPc-3 cells Capan-1 cells MIA PaCa-2 cells E3LZ10.7 cells A10.7 cells INS-1 cells MIN-6 cells Origin:
Species:
Tissue:
Morphology:
Properties:
Medium:
Subculture:
Freezing Medium:
Biosafety Level:
Sterility:
Pathogens:
Insulin Responsiveness:
Related cells by Organ:
References for MIN-6 cells:
1. Ishihara, H., Asano, T., Tsukuda, K. et al. (1993). Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia 36(11), 1139-1145.
2. Bao L, Fu X, Si M, Wang Y, Ma R, Ren X, Lv H. MicroRNA-185 Targets SOCS3 to Inhibit Beta-Cell Dysfunction in Diabetes. PLoS One. 2015 Feb 6;10(2):e0116067. PMID: 25658748
3. Mayer C, Bergholdt R, Cucak H, Rolin BC, Sams A, Rosendahl A.Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without AffectingHbA1c in Type 2 Diabetic db/db Mice. PLoS One. 2015 Jul 10;10(7):e0131306. PMID: 26162095
4. Fortin JS, Benoit-Biancamano MO, C-Gaudreault R. Discovery of ethyl urea derivatives as inhibitors of islet amyloid polypeptide fibrillization and cytotoxicity. Can J Physiol Pharmacol. 2016 Mar;94(3):341-346. PMID: 26679837
5. Chang TJ, Tseng HC, Liu MW, Chang YC, Hsieh ML, Chuang LM. Glucose-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improvingmitochondrial function and suppressing prolonged AMPK activation.Sci Rep. 2016 Mar 21;6:23403. doi: 10.1038/srep23403. PMID: 26997114
6. Huang LP, Kirschke CP. Down-regulation of zinc transport 8 (SLC30A8) in pancreatic beta-cells promotes cell survival. Austin Journal of Endocrinology and Diabetes. 2016;3(1):1037.
7. Silvander JSG, Kvarnström SM, Kumari-Ilieva A, Shrestha A, Alam CM, Toivola DM. Keratins regulate beta-cell mitochondrial morphology, motility, and homeostasis. FASEB J. 2017 Oct;31(10):4578-4587. PMID: 28666985
8. Elliott AD, Bedard N, Ustione A, Baird MA, Davidson MW, Tkaczyk T, Piston DW. Hyperspectral imaging for simultaneous measurements of two FRET biosensors in pancreatic beta-cells. PLoS One. 2017 Dec 6;12(12):e0188789. doi: 10.1371/journal.pone.0188789. PMID: 29211763
9. Velasquez C, Vasquez JS, Balcazar N. In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic beta-Cells. Diabetes Metab J. 2017 Aug;41(4):303-315. doi: 10.4093/dmj.2017.41.4.303. PMID: 28868828