Clinisciences > NFE2L2 Antibody - middle region
NFE2L2 Antibody - middle region
Marke : Aviva Systems Biology
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Datasheets/Manuals | Printable datasheet for anti-NFE2L2 (OAGA02126) antibody |
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Predicted Species Reactivity | Human, Mouse, Rat, Alligator, Bird, Plant |
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Product Format | Liquid. 1XPBS, 1% BSA, 20% Glycerol (pH 7). 0.025% ProClin 300 was added as a preservative. |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Application | CLIA |
Additional Information | Positive Controls: C8D30 , 3xFlag-human NFE2L2-transfected 293T , MDA-MB-231 nuclear extract , MDA-MB-231 nuclear extract (30uM tBHQ, 4hr) , HepG2 (10 uM MG132 treatment for 15 hr) Cellular Localization: Cytoplasm , cytosol , Nucleus |
Reconstitution and Storage | Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles. |
Immunogen | Recombinant protein encompassing a sequence within the center region of human NRF2. The exact sequence is proprietary. |
Purification | Purified by antigen-affinity chromatography. |
Predicted Homology Based on Immunogen Sequence | Rhesus Monkey (99%), Bovine (84%) |
Concentration | 0.11 mg/ml |
Application Info | ICC/IF: 1:100-1:1000 IHC-P 1:100-1:1000 IP 1:100-1:500 WB 1:500-1:3000 CHIP: Assay-dependent dilution IHC: Assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. |
Gene Symbol | NFE2L2 |
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Gene Full Name | nuclear factor, erythroid 2-like 2 |
Alias Symbols | NRF2, HEBP1, Nrf-2, IMDDHH |
NCBI Gene Id | 4780 |
Description of Target | NFE2 , NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, although remaining regions have diverged considerably from each other. |
Uniprot ID | Q16236 |
Molecular Weight | 68 kDa |
Protein interactions
Name | # of Products | |
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ATF4 | 87 | |
BACH1 | 55 | |
CASP1 | 98 | |
CASP3 | 324 | |
CDKN1A | 474 | |
CHD6 | 19 | |
COPS7A | 58 | |
CREBBP | 802 | |
CUL3 | 124 | |
EIF2AK3 | 19 | |
GADD45GIP1 | 17 | 324 |
JUND | 52 | |
KEAP1 | 137 | |
MAF | 45 | |
MAFF | 39 | |
MAFG | 36 | |
MAFK | 40 | |
MYC | 816 | |
NCOR1 | 286 | |
NCOR2 | 298 | |
NFE2 | 53 | |
PMF | 6 | |
PMF1 | 31 | |
PPARG | 168 | |
PRKCA | 529 | |
PRKCD | 293 | |
PRKCG | 137 | |
PRKCH | 56 | |
PRKCQ | 83 | |
SMARCA4 | 392 | |
SQSTM1 | 172 | |
TRIM24 | 85 | |
UBC | 7030 | |
YY1 | 211 |
Biological pathways
Name | # of Products |
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Transcription from RNA polymerase II promoter | 338 |
Biological process
Name | # of Products |
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Cellular response to oxidative stress | 28 |
Endoplasmic reticulum unfolded protein response | 72 |
Positive regulation of blood coagulation | 14 |
Positive regulation of reactive oxygen species metabolic process | 31 |
Positive regulation of transcription from RNA polymerase II promoter | 968 |
Regulation of embryonic development | 10 |
Regulation of removal of superoxide radicals | 5 |
Regulation of transcription, DNA-dependent | 1734 |
Transcription from RNA polymerase II promoter | 302 |
Cellular components
Name | # of Products |
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Centrosome | 253 |
Chromatin | 82 |
Cytoplasm | 4549 |
Cytosol | 1868 |
Nucleus | 4914 |
Plasma membrane | 2678 |
Protein function
Name | # of Products |
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DNA binding | 3958 |
Protein dimerization activity | 271 |
Protein domain specific binding | 530 |
Sequence-specific DNA binding | 1803 |
Sequence-specific DNA binding transcription factor activity | 2776 |
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