8505C cells
Cat# C0025002
Size : OneFrozenvial
Contact local distributor :
Disease:
Thyroid carcinoma, undifferentiated Established from undifferentiated thyroid carcinomas Homo sapiens Thyroid gland Epithelial Adherent Tumorigenic Female, 78 yrs of age RPMI1640 + 10% FBS 1:3 to 1:4 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37°C Complete culture medium supplemented with 5% (v/v) DMSO Bacteria: Negative Yeast: Negative Mycoplasma: Negative HIV: Negative Hepatitis B: Negative Hepatitis C: Negative 8505C cells FTC-238 cells K1 cells Origin:
Species:
Tissue:
Morphology:
Properties:
Cytogenic data:
Patient:
Medium:
Subculture:
Freezing Medium:
Biosafety Level:
I Sterility:
Pathogens:
Protein Expression:
cytokeratin +, cytokeratin-7 +, cytokeratin-8 +, cytokeratin-17 -, cytokeratin-18 +, cytokeratin-19 +, desmin -, endothel -, EpCAM +, GFAP -, HMB-45 -, neurofilament -, thyroglobulin -, vimentin + Related cells by Organ:
References for 8505C cells:
1. Ribeiro, F. R., Meireles, A. M., Rocha, A. S., and Teixeira, M. R. Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples. BMC Cancer, 8: 371, 2008.
2. Schweppe, R. E., Klopper, J. P., Korch, C., Pugazhenthi, U., Benezra, M., Knauf, J. A., Fagin, J. A., Marlow, L. A., Copland, J. A., Smallridge, R. C., and Haugen, B. R. Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab, 93: 4331-4341, 2008.
3. Arlot-Bonnemains, Y., Baldini, E., Martin, B., Delcros, J. G., Toller, M., Curcio, F., Ambesi-Impiombato, F. S., D'Armiento, M., and Ulisse, S. Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines. Endocr Relat Cancer, 15: 559-568, 2008.
4. Ito, T., Seyama, T., Hayashi, Y., Hayashi, T., Dohi, K., Mizuno, T., Iwamoto, K., Tsuyama, N., Nakamura, N., and Akiyama, M. Establishment of 2 human thyroid-carcinoma cell-lines (8305c, 8505c) bearing p53 gene-mutations. Int J Oncol, 4: 583-586, 1994.
5. Nucera, C., Nehs, M. A., Mekel, M., Zhang, X., Hodin, R., Lawler, J., Nose, V., and Parangi, S. A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid, 19: 1077-1084, 2009.
6. Lin, S. F., , D. L., Chen, C. H., Brader, P., Li, S., Gonzalez, L., Zhang, Q., Yu, Y. A., Chen, N., Szalay, A. A., Fong, Y., and Wong, R. J. Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo. J Clin Endocrinol Metab, 93: 4403-4407, 2008.
7. Zhu, W., Ou, Y., Li, Y., Xiao, R., Shu, M., Zhou, Y., Xie, J., He, S., Qiu, P., and Yan, G. A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway. Mol Pharmacol, 75: 812-819, 2009.