Anti-ADCY7 antibody {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100-1:200 ICC: 1:100-1:200 IF: 1:100-1:200 CFM: 1:100-1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Adcy7
Gene ID:	11513
Uniprot ID:	ADCY7_MOUSE
Specificity:	Does not cross react with other Adenylate cyclases.
Immunogen:	Synthetic peptide corresponding to unique amino acid sequence on mouse Particulate Adenylyl Cyclase 7 protein.

Tissue Specificity	Most abundant in heart, spleen and lung.
Post Translational Modifications	Phosphorylated by PRKCD.
Function	Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells.
Protein Name	Adenylate Cyclase Type 7 Atp Pyrophosphate-Lyase 7 Adenylate Cyclase Type Vii Adenylyl Cyclase 7
Database Links	Reactome: R-MMU-163615 Reactome: -MMU-170660 Reactome: -MMU-170670 Reactome: -MMU-418597 Reactome: -MMU-5610787
Cellular Localisation	Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Adenylate Cyclase Type 7 antibody Anti-Atp Pyrophosphate-Lyase 7 antibody Anti-Adenylate Cyclase Type Vii antibody Anti-Adenylyl Cyclase 7 antibody Anti-Adcy7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance