Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE
Cat# D204-5
Size : 50Tests
Brand : MBL International
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Phone : +1 850 650 7790
Please Note: MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: https://www.cosmobiousa.com/. For Non-US inquiries reach out to MBL in Japan: https://www.mblbio.com/.
D204-5
Antibody
50 tests
Monoclonal antibody conjugated to PE of 50 tests targeting CAMPATH-1/CD52 for FCM.
| Target | CAMPATH-1/CD52 |
|---|---|
| Product Type | Antibody |
| Application | FCM |
| Clonality | Monoclonal |
| Conjugate | PE |
| Isotype | IgG2a |
| Immunogen | Transgenic mouse spleen cell IL-2Ralpha |
| Host Species | Rat |
| Species Reactivity | Mouse |
| Formulation | PBS/1% BSA/0.09% NaN3 |
| Research Area | Immunology, Cell Biology |
| Description/Background | CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. CAMPATH-1 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1 antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~ 8-9 kDa as confirmed by total structure analysis and mass spectrometry. |
| Storage Temperature | 4°C |
| Protocols | FCM |
| Clone Number | BTG-2G |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
D204-5
Antibody
50 tests