General Info
Host: | Rabbit |
Applications: | WB/IHC/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-NSDHL (1-240) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | NSDHL |
Gene ID: | 50814 |
Uniprot ID: | NSDHL_HUMAN |
Immunogen Region: | 1-240 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human NSDHL (NP_057006.1). |
Immunogen Sequence: | MEPAVSEPMRDQVARTHLTE DTPKVNADIEKVNQNQAKRC TVIGGSGFLGQHMVEQLLAR GYAVNVFDIQQGFDNPQVRF FLGDLCSRQDLYPALKGVNT VFHCASPPPSSNNKELFYRV NYIGTKNVIETCKEAGVQKL ILTSSASVIFEGVDIKNGTE DLPYAMKPIDYYTETKILQE RAVLGANDPEKNFLTTAIRP HGIFGPRDPQLVPILIEAAR NGKMKFVIGNGKNLVDFTF |
Description
Tissue Specificity | Brain, heart, liver, lung, kidney, skin and placenta. |
Function | Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis. Also plays a role in the regulation of the endocytic trafficking of EGFR. |
Protein Name | Sterol-4-Alpha-Carboxylate 3-Dehydrogenase - DecarboxylatingProtein H105e3 |
Database Links | Reactome: R-HSA-191273 |
Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinLipid DropletTrafficking Through The Golgi Is Necessary For Er Membrane Localization |
Alternative Antibody Names | Anti-Sterol-4-Alpha-Carboxylate 3-Dehydrogenase - Decarboxylating antibodyAnti-Protein H105e3 antibodyAnti-NSDHL antibodyAnti-H105E3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance