Anti-PPP1CA antibody (N-Term)

Clonality:	Monoclonal
Conjugation:	Unconjugated
Formulation:	Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol.
Purification:	Affinity purification
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-1:2000 IF 1:100-1:500
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PPP1CA
Gene ID:	5499
Uniprot ID:	PP1A_HUMAN
Immunogen Region:	N-Term
Specificity:	PP1 Alpha Monoclonal Antibody detects endogenous levels of PP1 Alpha protein.
Immunogen:	Purified recombinant human PP1 Alpha (N-terminus) protein fragments expressed in E.coli.

Function	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy. (Microbial infection) Necessary for alphaviruses replication.
Protein Name	Serine/Threonine-Protein Phosphatase Pp1-Alpha Catalytic Subunit Pp-1a
Database Links	Reactome: R-HSA-163560 Reactome: R-HSA-180024 Reactome: R-HSA-2173788 Reactome: R-HSA-400253
Cellular Localisation	Cytoplasm Nucleus Nucleoplasm Nucleolus Primarily Nuclear And Largely Excluded From The Nucleolus Highly Mobile In Cells And Can Be Relocalized Through Interaction With Targeting Subunits Nom1 Plays A Role In Targeting This Protein To The Nucleolus In The Presence Of Ppp1r8 Relocalizes From The Nucleus To Nuclear Speckles Shuttles Toward The Cytosol During Infection With Veev
Alternative Antibody Names	Anti-Serine/Threonine-Protein Phosphatase Pp1-Alpha Catalytic Subunit antibody Anti-Pp-1a antibody Anti-PPP1CA antibody Anti-PPP1A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance