General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-RGS20 (1-241) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | RGS20 |
| Gene ID: | 8601 |
| Uniprot ID: | RGS20_HUMAN |
| Immunogen Region: | 1-241 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-241 of human RGS20 (NP_003693.2). |
| Immunogen Sequence: | MRTADGGEPAGASSPAGRVD GGLQMGSERMEMRKRQMPAA QDTPGAAPGQPGAGSRGSNA CCFCWCCCCSCSCLTVRNQE DQRPTIASHELRADLPTWEE SPAPTLEEVNAWAQSFDKLM VTPAGRNAFREFLRTEFSEE NMLFWMACEELKKEANKNII EEKARIIYEDYISILSPKEV SLDSRVREVINRNMVEPSQH IFDDAQLQIYTLMHRDSYPR FMNSAVYKDLLQSLSEKSI |
Description
| Tissue Specificity | Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe. |
| Post Translational Modifications | Fatty acylated. Heavily palmitoylated in the cysteine string motif. N- and O-glycosylated in synapsomal membranes. Serine phosphorylated in synapsomal membranes. Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits. |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. |
| Protein Name | Regulator Of G-Protein Signaling 20Rgs20Gz-Selective Gtpase-Activating ProteinG(ZgapGz-GapRegulator Of G-Protein Signaling Z1Regulator Of Gz-Selective Protein Signaling 1 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-418597 |
| Cellular Localisation | MembraneLipid-AnchorNucleusCytoplasmShuttles Between The Cytoplasm/Cell Membrane And The NucleusAnchored To The Membrane Through Palmitoylation |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 20 antibodyAnti-Rgs20 antibodyAnti-Gz-Selective Gtpase-Activating Protein antibodyAnti-G(Zgap antibodyAnti-Gz-Gap antibodyAnti-Regulator Of G-Protein Signaling Z1 antibodyAnti-Regulator Of Gz-Selective Protein Signaling 1 antibodyAnti-RGS20 antibodyAnti-RGSZ1 antibodyAnti-ZGAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance