Anti-Substance P antibody (1-100)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:500 IF/ICC 1:100-1:500
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	TAC1
Gene ID:	6863
Uniprot ID:	TKN1_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Substance P (NP_003173.1).
Immunogen Sequence:	MKILVALAVFFLVSTQLFAE EIGANDDLNYWSDWYDSDQI KEELPEPFEHLLQRIARRPK PQQFFGLMGKRDADSSIEKQ VALLKALYGHGQISHKRHKT

Post Translational Modifications	Substance P: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Function	Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Protein Name	Protachykinin-1 Ppt Cleaved Into - Substance P - Neurokinin A Nka Neuromedin L Substance K - Neuropeptide K Npk - Neuropeptide Gamma - C-Terminal-Flanking Peptide
Database Links	Reactome: R-HSA-380095 Reactome: R-HSA-416476
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Protachykinin-1 antibody Anti-Ppt Cleaved Into - Substance P - Neurokinin A antibody Anti-Nka antibody Anti-Neuromedin L antibody Anti-Substance K - Neuropeptide K antibody Anti-Npk - Neuropeptide Gamma - C-Terminal-Flanking Peptide antibody Anti-TAC1 antibody Anti-NKA antibody Anti-NKNA antibody Anti-TAC2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance