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Reagents and instruments for immunology, cell biology and molecular biology.

Camostat Mesilate [59721-29-8]

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Cat# B2082-10mg

Size : 10mg

Contact local distributor :

Phone : +1 850 650 7790

Brand : APExBIO Technology

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Contact local distributor :

Phone : +1 850 650 7790

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Background

Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

Product Citation

1. Ann-Kathrin Reuschl, et al. "Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants." Nat Microbiol. 2024 Feb;9(2):451-463. PMID: 38228858

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	494.52
Cas No.	59721-29-8
Formula	C₂₀H₂₂N₄O₅·CH₄O₃S
Solubility	insoluble in EtOH; ≥160.6 mg/mL in DMSO; ≥32.15 mg/mL in H2O
Chemical Name	[4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate;methanesulfonic acid
SDF	Download SDF
Canonical SMILES	CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]
Cell lines	Rat primary hepatic stellate cells (HSCs)
Reaction Conditions	500 μmol/L camostat mesilate for 7 d incubation
Applications	Camostat mesilate (500 μmol/L) inhibited generation of transforming growth factor β (TGF-β) by suppressing plasmin activity and reduced the activity of TGF-β, which blocked in vitro activation of HSCs.
Animal experiment:[1]
Animal models	Male Wistar rats
Dosage form	1 ~ 2 mg/g Diet
Applications	Camostat mesilate (1 ~ 2 mg/g of diet) markedly attenuated an increase in hepatic plasmin and TGF-β levels, HSC activation, and hepatic fibrosis without apparent systemic or local side effects in porcine serum-treated rats. Therefore, camostat mesilate prevented porcine serum-induced rat hepatic fibrosis via a profound reduction in TGF-β generation
Note	The technical data provided above is for reference only.
	References: 1. Okuno M, Akita K, Moriwaki H, et al. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology, 2001, 120(7): 1784-1800.

Quality Control

Purity = 99.35%