CFTR Human Gene Knockout Kit (CRISPR)
Cat# KN216476LP
Size : 1kit
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CFTR Human Gene Knockout Kit (CRISPR)
SKU
KN216476LP
CFTR - human gene knockout kit via CRISPR, HDR mediated
4 Weeks*
| Product Data | |
| Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
|---|---|
| Vector | Luciferase-Puro |
| Target Symbol | CFTR |
| Locus ID | 1080 |
| Components | KN216476G1, CFTR gRNA vector 1 in pCas-Guide CRISPR vector KN216476G2, CFTR gRNA vector 2 in pCas-Guide CRISPR vector KN216476LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_000492 |
| UniProt ID | P13569 |
| Synonyms | ABC35; ABCC7; CF; CFTR/MRP; dJ760C5.1; MRP7; TNR-CFTR |
| Summary | This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| GA100776 | CFTR CRISPRa kit - CRISPR gene activation of human CF transmembrane conductance regulator | 1 kit | | |
| KN216476 | CFTR - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN216476BN | CFTR - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN216476RB | CFTR - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN416476 | CFTR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.