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> Deoxycholic acid-d6

Deoxycholic acid-d6

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Cat# HY-N0593S2-5mg

Size : 5mg

Brand : MedChemExpress

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Deoxycholic acid-d6 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

For research use only. We do not sell to patients.

Deoxycholic acid-d<sub>6</sub> Chemical Structure

Deoxycholic acid-d6 Chemical Structure

This product is a controlled substance and not for sale in your territory.

Description

Deoxycholic acid-d6 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deoxycholic acid-d6 Related Antibodies
Molecular Weight

398.61

Formula

C24H34D6O4
Unlabeled CAS

83-44-3
SMILES

C[C@@]12[C@](CC[C@]2(19)[C@H](C)CCC(O)=O)(19)[C@@]3(19)[C@@](C([2H])([2H])[C@@H]1O)(19)[C@@]4([C@](C([2H])([2H])[C@H](O)C([2H])([2H])C4)(19)CC3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

    [2]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809.  [Content Brief]

    [3]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.  [Content Brief]

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809.

    [3]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.

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Deoxycholic acid-d6 Related Classifications

  • Metabolic Disease
  • Others GPCR/G Protein Metabolic Enzyme/Protease
  • Isotope-Labeled Compounds G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deoxycholic acid-d6Cholanoic Acid-d6Desoxycholic acid-d6Isotope-Labeled CompoundsG protein-coupled Bile Acid Receptor 1Endogenous MetaboliteG-protein coupled receptor 19GPCR19TGR5GPBAR1Inhibitorinhibitorinhibit