ET-2/Endothelin 2 Polyclonal Antibody, AbBy Fluor® 680 Conjugated

Cat# bs-11280R-BF680

Size : 100ul

Brand : Bioss

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ET-2/Endothelin 2 Polyclonal Antibody, AbBy Fluor® 680 Conjugated

Applications

  • IF(IHC-P)
  • IF(IHC-F)
  • IF(ICC)

Reactivity

  • Cat

Predicted Reactivity

  • Human
  • Mouse
  • Rat
  • Dog
  • Cow
  • Cat
  • Rabbit
Overview
Catalog # bs-11280R-BF680
Product Name ET-2/Endothelin 2 Polyclonal Antibody, AbBy Fluor® 680 Conjugated
Applications IF(IHC-P), IF(IHC-F), IF(ICC)
Reactivity Cat
Predicted Reactivity Human, Mouse, Rat, Dog, Cow, Cat, Rabbit
Specifications
Conjugation AbBy Fluor® 680
Host Rabbit
Source KLH conjugated synthetic peptide derived from human Endolin 2
Immunogen Range 49-59/178
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Subcellular location Secreted
Synonyms EDN2; EDN2_HUMAN; Endothelin 2; Endothelin-2; ET 2; ET-2; ET2; PPET2; Preproendothelin 2; Preproendothelin-2.
Background The endothelin (ET) family of proteins, which includes ET-1 (endothelin-1), ET-2 (endothelin-2) and ET-3 (endothelin-3), are vasoactive peptides that are involved in various functions throughout the body. Endothelins can affect the central nervous system and neuronal excitability, and they elicit potent vasoconstrictor action. While ET-1 is a potent, 21-amino acid vasoconstrictor peptide, ET-2 has the most potent vasoconstrictor activity. ET-3 functions as a ligand for endothelin receptor type B (ETBR) and, through this interaction, mediates the maturation of enteric neurons and melanocytes. Although ET-3 is expressed as a 238 amino acid peptide, it is post-translationally modified to produce a short active isoform and a long inactive isoform. Defects in the gene encoding ET-3 are the cause of a variety of disorders, including Hirschsprung disease type 1 (HSCR1), congenital central hypoventilation syndrome (CCHS) and Waardenburg syndrome type IV (WS4).
Application Dilution
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200