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> Imeglimin [775351-65-0]

Imeglimin [775351-65-0]

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Cat# HY-14771-5mg

Size : 5mg

Brand : MedChemExpress

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Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Imeglimin hydrochloride) that retains the same biological activity.

For research use only. We do not sell to patients.

Imeglimin Chemical Structure

Imeglimin Chemical Structure

CAS No. : 775351-65-0

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Imeglimin:

Imeglimin hydrochloride
Description

Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].

IC50 & Target

ROS; mitochondrial function[1]
In Vitro

Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Imeglimin Related Antibodies

Cell Viability Assay[2]

Cell Line: Human endothelial cells (HMEC-1)
Concentration: 100 μM and10 mM
Incubation Time: 100 μM for 24 h, 10 mM for 4 h
Result: Prevention of cell death.
In Vivo

Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, restores normal glucose tolerance, and improves insulin sensitivity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6JOlaHsd mice (4 weeks old)[1]
Dosage: 200 mg/kg
Administration: Oral gavage; b.i.d.; 6 weeks
Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
Clinical Trial
Molecular Weight

155.20

Formula

C6H13N5
CAS No.

775351-65-0

SMILES

NC1=N[C@@H](C)N=C(N(C)C)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References

  • [1]. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64.  [Content Brief]

    [2]. Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072.  [Content Brief]

  • [1]. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64.

    [2]. Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072.

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Imeglimin Related Classifications

  • Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  • Mitochondrial Metabolism Reactive Oxygen Species

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Help & FAQs

  • Keywords:

    Imeglimin775351-65-0EMD 387008EMD387008EMD-387008Mitochondrial MetabolismReactive Oxygen SpeciesoralglucoseloweringinsulinsensitivityROSmitochondrialfunctionInhibitorinhibitorinhibit

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