Interleukin-1 Receptor Antagonist Protein (Human)

Interleukin-1 Receptor Antagonist Protein
Catalog number: B2010261
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 50 ug
pH: n/a
Supplied as: Reconstitute before use
Appearance: Solid
Applications: highly pure recombinant (expressed in HEK293 cells) Human Interleukin-1 Receptor Antagonist Protein. This protein is a member of the IL-1 family and interacts with the IL-1 receptors.
Storage: -20C
Keywords: rHuIL-1RA; IL-1RN; IRAP
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through0.22 um.

References:
1: Xie R, Zhang Y, Zhao N, Zhou S, Wang X, Han W, Yu Y, Zhao X, Cui Y.
Pharmacokinetics and Safety of Recombinant Human Interleukin-1 Receptor
Antagonist GR007 in Healthy Chinese Subjects. Eur J Drug Metab Pharmacokinet.
2019 Jun;44(3):353-360.

2: Mehta S, Akhtar S, Porter RM, Önnerfjord P, Bajpayee AG. Interleukin-1
receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced
catabolism in cartilage-synovium co-culture than in cartilage monoculture.
Arthritis Res Ther. 2019 Nov 13;21(1):238.

3: Helmy A, Guilfoyle MR, Carpenter KL, Pickard JD, Menon DK, Hutchinson PJ.
Recombinant human interleukin-1 receptor antagonist in severe traumatic brain
injury: a phase II randomized control trial. J Cereb Blood Flow Metab. 2014
May;34(5):845-51.

4: Thom G, Tian MM, Hatcher JP, Rodrigo N, Burrell M, Gurrell I, Vitalis TZ,
Abraham T, Jefferies WA, Webster CI, Gabathuler R. A peptide derived from
melanotransferrin delivers a protein-based interleukin 1 receptor antagonist
across the BBB and ameliorates neuropathic pain in a preclinical model. J Cereb
Blood Flow Metab. 2019 Oct;39(10):2074-2088.

5: Spinello A, Vecile E, Abbate A, Dobrina A, Magistrato A. How Can
Interleukin-1 Receptor Antagonist Modulate Distinct Cell Death Pathways? J Chem
Inf Model. 2019 Jan 28;59(1):351-359.

6: Clements AEB, Groves ER, Chamberlain CS, Vanderby R, Murphy WL.
Microparticles Locally Deliver Active Interleukin-1 Receptor Antagonist In Vivo.
Adv Healthc Mater. 2018 Aug;7(16):e1800263.

7: Arthur VL, Shuldiner E, Remmers EF, Hinks A, Grom AA, Foell D, Martini A,
Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED,
Russo R, Len C, Oliveira S, Yeung RSM, Rosenberg AM, Wedderburn LR, Anton J,
Haas JP, Rösen-Wolff A, Minden K, Szymanski AM; INCHARGE Consortium, Thomson W,
Kastner DL, Woo P, Ombrello MJ. IL1RN Variation Influences Both Disease
Susceptibility and Response to Recombinant Human Interleukin-1 Receptor
Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis. Arthritis
Rheumatol. 2018 Aug;70(8):1319-1330.

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