Mouse Anti-Human IL-21-BIOT
Cat# 15910-08
Size : 0.5mg
Brand : Southern Biotech
Clone | SB134f |
---|---|
Isotype | Mouse (BALB/c) IgG2aκ |
Isotype Control | Mouse IgG2a-BIOT (HOPC-1) |
Specificity | Human IL-21 |
Alternative Names | Interleukin-21, Za11 |
Description | Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases. |
Immunogen | E. coli-expressed human IL-21 |
Conjugate | BIOT (Biotin) |
Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
Clonality | Monoclonal |
Concentration | 0.5 mg/mL |
Volume | 1.0 mL |
Recommended Storage | 2-8°C |
Applications | ELISA – Quality tested Note – May be paired with the purified clone SB134b (SB Cat. No. 15900-01) in a sandwich ELISA |
RRID Number | AB_2794998 |
Gene ID | 59067 (Human) |
Gene ID Symbol | IL21 (Human) |
Gene ID Aliases | CVID11; IL-21; Za11 |
UniProt ID | Q9HBE4 (Human |
UniProt Name | IL21_HUMAN (Human) |
Documentation
Technical Bulletin Safety Datasheet
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