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Mouse Monoclonal Anti-CD56 / NCAM1 (Neuronal Cell Marker) [Clone SPM128]
Cat# NB-36-00558X-P1
Size : 100ug
Brand : Neo Biotech
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Printable Datasheet
CD56 / NCAM1 (Neuronal Cell Marker) Antibody [SPM128]
Catalog Number Formulation Size Price
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human Pancreas stained with CD56 Monoclonal Antibody (SPM128)
FACS analysis of CD56 on human Monocytes using CD56 Monoclonal Antibody (SPM128)
Applications & Dilutions
Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Summary
This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
Product Properties & Targets
Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry
Species Reactivity
Human, Rat, Zebrafish
Research Areas
Autophagy, Cardiovascular, Immunology, Neuroscience, Signal Transduction
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
NCAM1
Positive Control
Cerebellum, Neuroblastoma., Pancreas
Immunogen
Membrane preparation of a small cell lung carcinoma
Alternate Names
Neural cell adhesion molecule 1, NCAM, Leu-19, NKH1, MSK39, NCAM120, NCAM140, NCAM180, Neural Cell Adhesion Molecule
Functions
- This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
- (Microbial infection) Acts as a receptor for rabies virus.
- (Microbial infection) Acts as a receptor for Zika virus.
Key References
- Hilkens et al., Int J Cancer. 1984 34:197-206.
- Kibbelaar et al. Eur. J. Cancer 1991 27:431-435.
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/3253057/
- https://pubmed.ncbi.nlm.nih.gov/1710251/
- https://pubmed.ncbi.nlm.nih.gov/8075973/
- https://pubmed.ncbi.nlm.nih.gov/14702039/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/1339414/
- https://pubmed.ncbi.nlm.nih.gov/2887295/
- https://pubmed.ncbi.nlm.nih.gov/3203385/
- https://pubmed.ncbi.nlm.nih.gov/9696812/
- https://pubmed.ncbi.nlm.nih.gov/16335952/
- https://pubmed.ncbi.nlm.nih.gov/24275569/
- https://pubmed.ncbi.nlm.nih.gov/32753727/
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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