N-Acetylneuraminic acid [131-48-6]
Cat# HY-I0400-100mg
Size : 100mg
Brand : MedChemExpress
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42, which is promising for research in the field of melanoma and coronary artery diseases.
For research use only. We do not sell to patients.
N-Acetylneuraminic acid Chemical Structure
CAS No. : 131-48-6
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Other Forms of N-Acetylneuraminic acid:
- N-Acetylneuraminic acid-13C Get quote
- N-Acetylneuraminic acid-13C-1 Get quote
- N-Acetylneuraminic acid-13C-2 Get quote
- N-Acetylneuraminic acid-13C-3 Get quote
Description |
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42, which is promising for research in the field of melanoma and coronary artery diseases[1][2][3]. |
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IC50 & Target |
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In Vitro |
N-Acetylneuraminic acid (0 - 2 mg/mL, 2 days) has no effect on cell proliferation, but significantly decreases tyrosinase protein level, the number of melanosomes, p62 protein level and increases CCT3, CCT5, LC3-II protein level mRNA levels in B16 melanoma cells[1]. N-Acetylneuraminic acid (0 - 500 μM, 12 h) specifically binds to RhoA and Cdc42 and activates Rho/ROCK-JNK/ERK signaling in cardiomyocytes[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Immunofluorescence[1]
Real Time qPCR[1]
Western Blot Analysis[1]
Cell Viability Assay[2]
Western Blot Analysis[2]
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In Vivo |
N-Acetylneuraminic acid (0 - 20 mg/kg, i.p., twice a day for 6 weeks) triggers myocardial injury in healthy rats[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Molecular Weight |
309.27 |
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Formula |
C11H19NO9 |
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CAS No. |
131-48-6 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](NC(C)=O)[C@@H](O)CC(C(O)=O)=O |
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Structure Classification |
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Initial Source |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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Solvent & Solubility |
In Vitro:
H2O : 125 mg/mL (404.18 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation | |||||||||||||||||||||||||||||||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 3.2334 mL | 16.1671 mL | 32.3342 mL | 80.8355 mL |
5 mM | 0.6467 mL | 3.2334 mL | 6.4668 mL | 16.1671 mL | |
10 mM | 0.3233 mL | 1.6167 mL | 3.2334 mL | 8.0836 mL | |
15 mM | 0.2156 mL | 1.0778 mL | 2.1556 mL | 5.3890 mL | |
20 mM | 0.1617 mL | 0.8084 mL | 1.6167 mL | 4.0418 mL | |
25 mM | 0.1293 mL | 0.6467 mL | 1.2934 mL | 3.2334 mL | |
30 mM | 0.1078 mL | 0.5389 mL | 1.0778 mL | 2.6945 mL | |
40 mM | 0.0808 mL | 0.4042 mL | 0.8084 mL | 2.0209 mL | |
50 mM | 0.0647 mL | 0.3233 mL | 0.6467 mL | 1.6167 mL | |
60 mM | 0.0539 mL | 0.2695 mL | 0.5389 mL | 1.3473 mL | |
80 mM | 0.0404 mL | 0.2021 mL | 0.4042 mL | 1.0104 mL | |
100 mM | 0.0323 mL | 0.1617 mL | 0.3233 mL | 0.8084 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Acetylneuraminic acid Related Classifications
- MAPK/ERK Pathway GPCR/G Protein Anti-infection Metabolic Enzyme/Protease
- Tyrosinase Ras Influenza Virus Endogenous Metabolite