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- Specifications
Product Description
PRF1 (Human) ELISpot Kit is a sandwich enzyme immunoassay for the quantitative measurement of Human PRF1.
Suitable Sample
Cell
Sample Volume
100 uL
Label
Biotin-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
- Applications
Quantification
- Gene Info — PRF1
Entrez GeneID
5551Gene Name
PRF1
Gene Alias
FLH2, HPLH2, MGC65093, P1, PFN1, PFP
Gene Description
perforin 1 (pore forming protein)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000019759|cytolysin|lymphocyte pore forming protein|perforin 1
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- Pathways
- Diseases