Reagents and instruments for immunology, cell biology and molecular biology.

PSMA I&S (TFA)

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Cat# HY-148152A-5mg

Size : 5mg

Contact local distributor :

Phone : +1 850 650 7790

Brand : MedChemExpress

Contact local distributor :

Phone : +1 850 650 7790

PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand.

For research use only. We do not sell to patients.

PSMA I&S TFA Chemical Structure

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Other Forms of PSMA I&S TFA:

PSMA I&S Get quote

Description

PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand^[1].

Molecular Weight

1413.43

Formula

C₆₁H₈₃F₃N₁₀O₂₃S

Appearance

Solid

Color

White to off-white

SMILES

OC(C=C1)=CC=C1C[C@@H](NC([C@@H](CO)NC([C@@H](CO)NC([C@@H](CO)NC(CS)=O)=O)=O)=O)C(N[C@@H](C(N[C@@H](C(O)=O)CCCCNC(CCCCCCC(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)CC2=CC3=C(C=CC=C3)C=C2)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (70.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7075 mL	3.5375 mL	7.0750 mL
5 mM	0.1415 mL	0.7075 mL	1.4150 mL
10 mM	0.0707 mL	0.3537 mL	0.7075 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (1.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (1.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.15%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (245 KB) RP-HPLC (249 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Robu S, et, al. Preclinical Evaluation and First Patient Application of 99mTc-PSMA-I&S for SPECT Imaging and Radioguided Surgery in Prostate Cancer. J Nucl Med. 2017 Feb;58(2):235-242. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7075 mL	3.5375 mL	7.0750 mL	17.6875 mL
	5 mM	0.1415 mL	0.7075 mL	1.4150 mL	3.5375 mL
	10 mM	0.0707 mL	0.3537 mL	0.7075 mL	1.7687 mL
	15 mM	0.0472 mL	0.2358 mL	0.4717 mL	1.1792 mL
	20 mM	0.0354 mL	0.1769 mL	0.3537 mL	0.8844 mL
	25 mM	0.0283 mL	0.1415 mL	0.2830 mL	0.7075 mL
	30 mM	0.0236 mL	0.1179 mL	0.2358 mL	0.5896 mL
	40 mM	0.0177 mL	0.0884 mL	0.1769 mL	0.4422 mL
	50 mM	0.0141 mL	0.0707 mL	0.1415 mL	0.3537 mL
	60 mM	0.0118 mL	0.0590 mL	0.1179 mL	0.2948 mL

PSMA I&S TFA Related Classifications

Immunology/Inflammation
PSMA

PSMA I&S (TFA)

Cat# HY-148152A-5mg

Contact local distributor :

Brand : MedChemExpress

Contact local distributor :

Other Forms of PSMA I&S TFA:

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

PSMA I&S TFA Related Classifications

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