Stemolecule™ Forskolin
04-0025
Brand: Stemolecule
Forskolin is a natural product adenylate cyclase activator that increases cyclic AMP levels.
- [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate
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Product Information
Stemolecule Forskolin is a natural compound produced by the Indian Coleus plant (Coleus forskohlii)1. It is used in several differentiation protocols for its ability to potentiate neuron differentiation2,3. Forskolin is able to stimulate adenylate cyclase activity and increases cyclic AMP4. Cyclic AMP is a signaling molecule and key regulator of critical enzymes in cellular processes5. For example, cAMP can bind to protein kinase A (PKA) regulatory subunit and activate PKA which acts as a negative regulator of the hedgehog signaling pathway6.
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Additional Publications
- Pan T; Chen Y; Zhuang Y; Yang F; Xu Y; Tao J; You K; Wang N; Wu T; Lin X; Wu F; Liu Y; Wang G; Li L-X. Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts. Stem Cell Res Therapy 10:364 (2019).
- Zhu S; Russ HA; Wang X; Zhang M; Ma T; Xu T; Tang S; Hebrok M; Deng S. Human pancreatic β-like cells converted from fibroblasts. Nature Commun 7:10080 (2016).
- Saxena S; Ronn RE; Guibentif C; Moragheba R; Woods N-B. Cyclic AMP signaling through Epac axis modulates human hemogenic endothelium and enhances hematopoeitic cell generation. Stem Cell Rep doi:10.1016/j.stemcr.2016.03.006 (2016).
- Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules. Stem Cells International 2016:4304916 (2016).