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Sulfadoxine

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Cat# M3604-5g

Size : 5g

Brand : AbMole Bioscience

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Phone : +1 850 650 7790

Sulfadoxine Structure
Synonym:

Sulphadoxine

Quality Control & Documentation
Biological Activity

Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 µg/ml for P. vivax. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either compound by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite’s environment, while in combination, the two substances have a synergistic effect which outbalances that ability.

Chemical Information
Molecular Weight 310.33
Formula C12H14N4O4S
CAS Number 2447-57-6
Form Solid
Solubility (25°C) Water 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Audrien Alves Andrade de Souza, et al. Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells

[2] Makoto Saito, et al. Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs

[3] Philip J Peters, et al. Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment

[4] C H Sibley, et al. Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

[5] H M McIntosh. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria