Vinblastine (sulfate) [143-67-9]
Cat# HY-13780-10mg
Size : 10mg
Brand : MedChemExpress
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
For research use only. We do not sell to patients.
Vinblastine sulfate Chemical Structure
CAS No. : 143-67-9
This product is a controlled substance and not for sale in your territory.
Based on 11 publication(s) in Google Scholar
Description |
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM. |
IC50 & Target |
IC50: 8.9 μM(nAChR)[1] |
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In Vitro |
Vinblastine does not depolymerize spindle microtubules, yet it powerfully blocks mitosis (for example, IC50 0.8 nM in HeLa cells) and cells die by apoptosis[2]. In NB4 cells, vinblastine produces alteration of p53 and DNA fragmentation. Vinblastine treatment has an antiproliferative effect via the induction of apoptosis producing Bax/Bcl-2 imbalance. Vinblastine treatment suppresses NFκB expression and depresses NFκB-DNA binding activity while maintaining JNK activation that subsequently results in apoptotic response through caspase-dependent pathway[3]. Vinblastine is found to trigger apoptosis as evidenced by the loss of mitochondrial membrane potential, the release of both cytochrome c and apoptosis inducing factor, activation of caspase-9 and 3, and cleavage of Poly (ADP-ribose)-Polymerase[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Vinblastine is a widely used anticancer drug with undesired side effects. Its conjugation with carrier molecules could be an efficient strategy to reduce these side effects[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
909.05 |
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Formula |
C46H60N4O13S |
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CAS No. |
143-67-9 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
08[C@@]12C[C@@](C3=C(OC)C=C(N([C@]4(08)[C@@]56[C@]7(08)[C@](C=CCN7CC6)(CC)[C@@H](OC(C)=O)[C@@]4(C(OC)=O)O)C)C5=C3)(C(OC)=O)C(NC8=C9C=CC=C8)=C9CC[N@](C2)C[C@](O)(CC)C1.OS(=O)(O)=O |
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Structure Classification |
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Initial Source |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvent & Solubility |
In Vitro:
H2O : 50 mg/mL (55.00 mM; Need ultrasonic) DMSO : ≥ 44 mg/mL (48.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.04% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 1.1000 mL | 5.5002 mL | 11.0005 mL | 27.5012 mL |
5 mM | 0.2200 mL | 1.1000 mL | 2.2001 mL | 5.5002 mL | |
10 mM | 0.1100 mL | 0.5500 mL | 1.1000 mL | 2.7501 mL | |
15 mM | 0.0733 mL | 0.3667 mL | 0.7334 mL | 1.8334 mL | |
20 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3751 mL | |
25 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1000 mL | |
30 mM | 0.0367 mL | 0.1833 mL | 0.3667 mL | 0.9167 mL | |
40 mM | 0.0275 mL | 0.1375 mL | 0.2750 mL | 0.6875 mL | |
H2O | 50 mM | 0.0220 mL | 0.1100 mL | 0.2200 mL | 0.5500 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Vinblastine sulfate Related Classifications
- Cell Cycle/DNA Damage Cytoskeleton Autophagy
- Microtubule/Tubulin Autophagy