Z-VAD-FMK [161401-82-7]
Cat# HY-16658B-5mg
Size : 5mg
Brand : MedChemExpress
Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM.
For research use only. We do not sell to patients.
Z-VAD-FMK Chemical Structure
CAS No. : 161401-82-7
This product is a controlled substance and not for sale in your territory.
Based on 411 publication(s) in Google Scholar
Other Forms of Z-VAD-FMK:
- Z-VAD(OMe)-FMK In-stock
- Z-VA-DL-D-FMK Get quote
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2022 Jul;7(7):1041-1053. [Abstract]
- HFFs stably expressing UL37x1 or empty vector are infected with HCMV in the presence of z-VAD-FMK. At 0, 6 and 12 h.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: J Autoimmun. 2022 Sep 13;133:102904. [Abstract]
- C57BL/6 are treated with Concanavalin A (12 μg/g) alone or zVAD (20 μg/g) alone or zVAD (20 μg/g) + Concanavalin A (12 μg/g) at indicated times. The number of apoptotic cells in the zVAD + Concanavalin A treated group is markedly reduced compared with that observed in the ConA-treated group.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: J Autoimmun. 2022 Sep 13;133:102904. [Abstract]
- After being treated with zVAD (0, 20, 40, 80 μM) for 30 min, the BMDMs are followed by the administration of LPS (100 ng/ml) for 24 h.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: J Autoimmun. 2022 Sep 13;133:102904. [Abstract]
- The BMDMs are cultured with different concentrations of zVAD (0, 20, 40, 80, 100 μM) for 24 h.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Oct;56:102435. [Abstract]
- Primary HSCs and LX-2 cells are treated with EA (LX-2 cells: 40 μM; primary HSCs: 45 μM), Ferrostatin-1 (1 μM) and Z-VAD-FMK (10 μM), and cells are stained with PI (red fluorescence) to examine the dead cells.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Aug;54:102355.
- In CAL-27 cells, Z-VAD-FMK (50 μM; 4 hours) treatment counteracted the NRC-03-induced cytotoxicity and apoptosis.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Phytother Res. 2022 Oct 17. [Abstract]
- z-VAD-fmk (5 μM; 4 h) weakens CDBEE-induced apoptosis in MGC-803 and HGC-27 cells.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Nov 19;13:23-36. [Abstract]
- H1299 and H460 cells are treated with curcumenol with or without Z-VAD-FMK (10 μM) for 24 h, the cell viability is detected.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Feb 8;8(8):2002874. [Abstract]
- IB further confirmed the activation of the caspase‐dependent apoptotic pathway in OTUD1‐overexpressing cells with AIF ablation, which is diminished by VAD-FMK (50 μM).
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Feb 8;8(8):2002874. [Abstract]
- In vitro growth of KYSE30 cells expressing EV or OTUD1 and treated with or without Z‐VAD-FMK (50 μM).
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Feb 8;8(8):2002874. [Abstract]
- Representative image and statistical analyses of JC‐1 staining of KYSE30 cells expressing EV or OTUD1 and treated with DDP or Z‐VAD-FMK (50 μM). Z‐VAD-FMK treatment could not completely inhibit the proapoptotic function of OTUD1.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2021 May;11(5):1246-1260.
- Apoptosis of ECa109 and EC9706 cells treated with SFN (40 μM) and Z-VAD-FMK (20 μM) alone or combination for 48 h is analyzed by flow cytometry.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jun 19;10(17):7710-7729. [Abstract]
- When the cells were co-treated with Z-VAD-FMK (50 μM; 24 hours), the F-AgÅPs-induced inhibition of survival of 143B and SJSA-1 is significantly attenuated, as revealed by live/dead cell staining.
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Z-VAD-FMK purchased from MedChemExpress. Usage Cited in: Acta Biomater. 2020 Jun;109:229-243. [Abstract]
- The decreased cleaved caspase-3 and Bax proteins showed that Z-VAD successfully inhibited Chemo-PDT induced apoptosis.