20-hydroxycholesterol (Highly Pure)

Product Description

20-hydroxycholesterol (Highly Pure)
Catalog number: B2014819
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: N/A
Supplied as: N/A
Applications: molecular tool for various biochemical applications
Storage: RT
Keywords: 20-hydroxycholesterol
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Huang Y, Lin Y, Rong M, Liu W, He J, Zhou L. 20(S)-hydroxycholesterol and simvastatin synergistically enhance osteogenic differentiation of marrow stromal cells and bone regeneration by initiation of Raf/MEK/ERK signaling J Mater Sci Mater Med. 2019 Jul 19;30(8):87.
2: Faletrov YV, Efimova VS, Horetski MS, Tugaeva KV, Frolova NS, Lin Q, Isaeva LV, Rubtsov MA, Sluchanko NN, Novikova LA, Shkumatov VM. New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells Chem Phys Lipids. 2020 Mar;227:104850.
3: Adhikari R, Chen C, Kim WK. Effect of 20(S)-Hydroxycholesterol on Multilineage Differentiation of Mesenchymal Stem Cells Isolated from Compact Bones in Chicken Genes (Basel). 2020 Nov 17;11(11):1360.
4: CONSTANTOPOULOS G, TCHEN TT. Conversion of 20-alpha-hydroxycholesterol to pregnenolone Biochem Biophys Res Commun. 1961 Apr 28;4:460-3.
5: Mijares A, Cargill DI, Glasel JA, Lieberman S. Studies on the C-20 epimers of 20-hydroxycholesterol J Org Chem. 1967 Mar;32(3):810-2.
6: Kim WK, Meliton V, Amantea CM, Hahn TJ, Parhami F. 20(S)-hydroxycholesterol inhibits PPARgamma expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism J Bone Miner Res. 2007 Nov;22(11):1711-9.
7: Burstein S, Middleditch BS, Gut M. Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical preparations. Mode of oxygen incorporation J Biol Chem. 1975 Dec 10;250(23):9028-37.
8: HALL PF, KORITZ SB. INHIBITION OF THE BIOSYNTHESIS OF PREGNENOLONE BY 20-ALPHA-HYDROXYCHOLESTEROL Biochim Biophys Acta. 1964 Nov 8;93:441-4.
9: SHIMIZU K, DORFMAN RI, GUT M. Isocaproic acid, a metabolite of 20 alpha-hydroxycholesterol J Biol Chem. 1960 Jun;235:PC25.
10: Kim WK, Meliton V, Tetradis S, Weinmaster G, Hahn TJ, Carlson M, Nelson SF, Parhami F. Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells J Bone Miner Res. 2010 Apr;25(4):782-95.

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