Reagents and instruments for immunology, cell biology and molecular biology.

Anti-VDAC1 Antibody FL550 Conjugate

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Cat# 75-204-FL550

Size : 200uL

Contact local distributor :

Phone : +1 850 650 7790

Brand : Antibodies Incorporated

Contact local distributor :

Phone : +1 850 650 7790

Our Anti-VDAC1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N152B/23. It is KO validated, detects human, mouse, and rat VDAC1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

594

650

Data Sheet

KO Validated

SKU: 75-204-FL550

Product Details

Target

VDAC1

Target Description

Voltage-dependent anion-selective channel protein 1 or Outer Mitochondrial Membrane Protein Porin 1 is encoded by the gene VDAC1 and belongs to the mitochondrial porin family. VDAC1 is a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane and is also found on the plasma membrane of cells. VDAC1 can act as a scaffold for many proteins and allows for the passage of ions and metabolites, including ATP, through interactions within the pore. VDAC1 in the plasma membrane plays a role in the regulation of cell volume and apoptosis. VDAC1 is expressed in several tissues including heart, brain, liver and skeletal muscle. Diseases associated with VDAC1 include Influenza and Typhoid Fever.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N152B/23

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

VDAC1 VDAC

Molecular Weight

30 kDa

Antigen

Fusion protein amino acids 1-283 (full-length) of human VDAC1 (accession number P21796) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939757

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

Does not cross-react with VDAC2 or VDAC3 (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)

UniProt Details

UniProt (Human): P21796
UniProt (Immunogen Species): P21796

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