Azithromycin [83905-01-5]
Cat# HY-17506-1ml
Size : 10mM/1mL
Brand : MedChemExpress
Azithromycin is a macrolide antibiotic useful for the treatment of a number of bacterial infections.
For research use only. We do not sell to patients.
Azithromycin Chemical Structure
CAS No. : 83905-01-5
This product is a controlled substance and not for sale in your territory.
Based on 24 publication(s) in Google Scholar
Other Forms of Azithromycin:
- Azithromycin hydrate In-stock
- Azithromycin-13C,d3 In-stock
- Azithromycin-d3 Get quote
View All Antibiotic Isoform Specific Products:
View All Parasite Isoform Specific Products:
Description |
Azithromycin is a macrolide antibiotic useful for the treatment of a number of bacterial infections. |
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IC50 & Target |
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In Vitro |
Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells[1]. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
748.98 |
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Formula |
C38H72N2O12 |
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CAS No. |
83905-01-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
C[C@@H]([C@@H]([C@@](C(O[C@@H]([C@@](C)(O)[C@@H]1O)CC)=O)(11)C)O[C@@](O[C@@H](C)[C@@H]2O)(11)C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](CN([C@@H]1C)C)C)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)(11)[C@@H]3O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : ≥ 100 mg/mL (133.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: ≥98.0% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.3351 mL | 6.6757 mL | 13.3515 mL | 33.3787 mL |
5 mM | 0.2670 mL | 1.3351 mL | 2.6703 mL | 6.6757 mL | |
10 mM | 0.1335 mL | 0.6676 mL | 1.3351 mL | 3.3379 mL | |
15 mM | 0.0890 mL | 0.4450 mL | 0.8901 mL | 2.2252 mL | |
20 mM | 0.0668 mL | 0.3338 mL | 0.6676 mL | 1.6689 mL | |
25 mM | 0.0534 mL | 0.2670 mL | 0.5341 mL | 1.3351 mL | |
30 mM | 0.0445 mL | 0.2225 mL | 0.4450 mL | 1.1126 mL | |
40 mM | 0.0334 mL | 0.1669 mL | 0.3338 mL | 0.8345 mL | |
50 mM | 0.0267 mL | 0.1335 mL | 0.2670 mL | 0.6676 mL | |
60 mM | 0.0223 mL | 0.1113 mL | 0.2225 mL | 0.5563 mL | |
80 mM | 0.0167 mL | 0.0834 mL | 0.1669 mL | 0.4172 mL | |
100 mM | 0.0134 mL | 0.0668 mL | 0.1335 mL | 0.3338 mL |
Azithromycin Related Classifications
- Anti-infection Autophagy
- Bacterial Autophagy Antibiotic Parasite