Camostat Mesilate
Cat# M2487-10mg
Size : 10mg
Brand : AbMole Bioscience
FOY-305; Camostat mesylate; FOY-S980
Quality Control & Documentation
Biological Activity
Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
Chemical Information
Molecular Weight | 494.52 |
Formula | C20H22N4O5.CH4O3S |
CAS Number | 59721-29-8 |
Solubility (25°C) | DMSO 60 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Serap Şimşek-Yavuz, et al. An update of anti-viral treatment of COVID-19
[2] Peter Breining, et al. Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety
[3] Dwight L McKee, et al. Candidate drugs against SARS-CoV-2 and COVID-19
[4] Yoshiharu Uno. Camostat mesilate therapy for COVID-19
[5] Markus Hoffmann, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor