CBL (phospho Y700) monoclonal antibody, clone E1 (FITC)

Catalog # MAB23491
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Size:100 Reactions
Price: USD $ 531.00
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Flow Cytometry
Application

Flow Cytometry

Flow cytometric analysis of C6 cells with CBL (phospho Y700) monoclonal antibody, clone E1 (FITC) (Cat # MAB23491). Unstained treated with imatinib as negative control (blue) or stained treated with imatinib (red) or treated with pervanadate (green).

  • Specifications

    Product Description

    Rabbit monoclonal antibody raised against synthetic phosphopeptide of human CBL.

    Immunogen

    A synthetic phosphopeptide corresponding to residues surrounding Y700 of human CBL.

    Host

    Rabbit

    Reactivity

    Human, Mouse, Rat

    Form

    Liquid

    Conjugation

    FITC

    Purification

    Protein A/G purification

    Isotype

    IgG1, kappa

    Recommend Usage

    Flow Cytometry (5 uL/106 cells)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).

    Storage Instruction

    Store at 4°C.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Flow Cytometry

    Flow cytometric analysis of C6 cells with CBL (phospho Y700) monoclonal antibody, clone E1 (FITC) (Cat # MAB23491). Unstained treated with imatinib as negative control (blue) or stained treated with imatinib (red) or treated with pervanadate (green).
  • Gene Info — CBL

    Entrez GeneID

    867

    Gene Name

    CBL

    Gene Alias

    C-CBL, CBL2, RNF55

    Gene Description

    Cas-Br-M (murine) ecotropic retroviral transforming sequence

    Omim ID

    165360

    Gene Ontology

    Hyperlink

    Gene Summary

    The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq

    Other Designations

    oncogene CBL2

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