This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Dihydrostreptomycin sulfate
Catalog No. T2211 CAS 5490-27-7
Synonyms: Dihydrostreptomycin sesquisulfate
Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit. Dihydrostreptomycin Sulfate is a semi-synthetic aminoglycoside antibiotic with bactericidal properties. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tularemia.
All TargetMol products are for research or drug registration purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose in violation of laws and regulations.
Dihydrostreptomycin sulfate, CAS 5490-27-7
Pack Size
/USD
500 mg
In stock
1 g
In stock
Select Batch
Purity: 99.93%
Purity: 99.05%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description
Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit. Dihydrostreptomycin Sulfate is a semi-synthetic aminoglycoside antibiotic with bactericidal properties. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tularemia.
In vitro
The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins. It enters bacterial cells by binding to a specific site on MscL(mechanosensitive channel of large conductance) and modifying its conformation, thus allowing the passage of K+ and glutamate out of, and dihydrostreptomycin into, the cell[1].
In vivo
Dihydrostreptomycin sulfate would cause cochlea damage in mouse model and cell proliferation in the spiral ligament may occur after the dihydrostreptomycin sulfate -induced damage. This process is probably related to the recovery of cochlear function[2].
Kinase Assay
Briefly, the peptide substrate N-acetyl-Asp-Glu-Val-Asp-ρ-nitroanilide (Ac-DEVD-ρNA) is added to the cell lysates in assay buffer (50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 10 mM dithiothreitol, 1 mM EDTA, 10% glycerol) and incubated at 37°C. The cleavage of the substrate is monitored at 405 nm.
Synonyms
Dihydrostreptomycin sesquisulfate
Molecular Weight
730.71
Formula
C21H41N7O12·1·5H2SO4
CAS No.
5490-27-7
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 10 mM
DMSO: Insoluble
References and Literature
1. Kimitsuki T, et al. Brain Res. 1993, 624(1-2):143-150. 2. Yamashita H, et al. Acta Otolaryngol. 1999, 119(3):322-325.
Related compound libraries
This product is contained In the following compound libraries:
Natural Product Library Drug Repurposing Compound Library Natural Product Library for HTS Microbial Natural Product Library Anti-Infection Compound Library Antibiotics Library Approved Drug Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL),
Method for preparing in vivo formulation:Take μL DMSO master liquid, next add μL PEG300, mix and clarify, next add μL Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculator
Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
bottom
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.