EMD57033 [147527-31-9]
Cat# T25372-5mg
Size : 5mg
Brand : TargetMol
EMD57033
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Purity:99.72%
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COA LCMS ORP HPLC HNMR
EMD57033
Catalog No. T25372Cas No. 147527-31-9
EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. Pack Size | |
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5 mg | |
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500 mg |
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
Description | EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction. |
In vitro | EMD57033 (5.0 to 5.8 mumol/L) enhances contractility and prolongs relaxation. Its effects are modulated by heart rate, [Ca2+]o, and contraction mode, with positive inotropic effects being more prominent for ejecting beats.[4] |
In vivo | EMD-57033 (0.4 mg. kg(-1). min(-1) for 20 minutes) selective Ca(2+) sensitization with minimal PDE3I in vivo is achieved, improving basal and rate-stimulated contractility and mechanoenergetics of HF without compromising diastolic function. Despite PDE3I activity at higher doses, energetic benefits persist.[5] |
Alias | EMD-57033, (+)-EMD 57033, EMD 57033 |
Molecular Weight | 425.5 |
Formula | C22H23N3O4S |
Cas No. | 147527-31-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (117.51 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSO
main solution, add 300 μLPEG300
mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O
mix well and clarify
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Keywords
EMD57033