Reagents and instruments for immunology, cell biology and molecular biology.
 
> Leupeptin hemisulfate [103476-89-7]

Leupeptin hemisulfate [103476-89-7]

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Cat# 10-1346-25mg

Size : 25mg

Brand : Focus Biomolecules

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Leupeptin hemisulfate | Trypsin-like cysteine protease inhibitor

CAS:
103476-89-7
Catalog Number:
10-1346
Activity:
Trypsin-like cysteine protease inhibitor
Alternate Names:
Ac-Leu-Leu-Arg-CHO, hemisulfate
Molecular Weight:
475.59
Molecular Formula:
C20H38N6O4 &bul; 1/2H2SO4
Solubility:
Soluble in Water (up to 50 mg/ml). Also soluble in ethanol and methanol
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied Solutions in distilled water, ethanol or methanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size : Quantity 
25 mg$80.00
100 mg$240.00
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This product is also available in the following library:
Protease Inhibitors

Leupeptin hemisulfate (103476-89-7) is a reversible inhibitor of trypsin-like proteases and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B, H and L.1-3 Blocks various apoptotic pathways in T cells.4 Commonly used in cell lysis buffers to protect proteins from degradation. Typical working concentration is 1µM (0.5 µg/ml).

References/Citations:

1) Aoyagi et al. (1969), Leupeptins, new protease inhibitors from Actinomycetes; J. Antibiot., 22 283
2) Barrett et al. (1981), Cathepsin B, Cathepsin H and Cathepsin L; Methods Enzymol., Pt C, 80 535
3) Knight et al. (1980), Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin; Biochem. J., 189 447
4) Sarin et al. (1995), A protease-dependent TCR-induced death pathway in mature lymphocytes; J. Immunol., 154 5806

CAS:
103476-89-7
Catalog Number:
10-1346
Activity:
Trypsin-like cysteine protease inhibitor
Alternate Names:
Ac-Leu-Leu-Arg-CHO, hemisulfate
Molecular Weight:
475.59
Molecular Formula:
C20H38N6O4 &bul; 1/2H2SO4
Solubility:
Soluble in Water (up to 50 mg/ml). Also soluble in ethanol and methanol
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied Solutions in distilled water, ethanol or methanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Leupeptin hemisulfate (103476-89-7) is a reversible inhibitor of trypsin-like proteases and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B, H and L.1-3 Blocks various apoptotic pathways in T cells.4 Commonly used in cell lysis buffers to protect proteins from degradation. Typical working concentration is 1µM (0.5 µg/ml).

References/Citations:

1) Aoyagi et al. (1969), Leupeptins, new protease inhibitors from Actinomycetes; J. Antibiot., 22 283
2) Barrett et al. (1981), Cathepsin B, Cathepsin H and Cathepsin L; Methods Enzymol., Pt C, 80 535
3) Knight et al. (1980), Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin; Biochem. J., 189 447
4) Sarin et al. (1995), A protease-dependent TCR-induced death pathway in mature lymphocytes; J. Immunol., 154 5806

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