Ruxolitinib phosphate
Cat# M5944-5mg
Size : 5mg
Brand : AbMole Bioscience
Contact local distributor :
Phone : +1 850 650 7790
All AbMole products are for research use only, cannot be used for human consumption.
INCB018424 phosphate; INCB 018424 phosphate; INCB-018424 phosphate; Ruxolitinib
Quality Control & Documentation
Biological Activity
Ruxolitinib phosphate(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
Product Citations
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J Virol. 2020 Feb 14;94(5):e01791-19.
Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use
Ruxolitinib phosphate purchased from AbMole
Chemical Information
| Molecular Weight | 404.36 |
| Formula | C17H21N6O4P |
| CAS Number | 1092939-17-7 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL Water 8.2 mg/mL |
| Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Chen X, et al. Clin Pharmacol Drug Dev. Pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in renal and hepatic impairment patients.