APExBIO Technology
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APExBIO. As a premier provider of small molecule inhibitors/activators, compound libraries, peptides, assay kits, fluorescent labels, enzymes, modified nucleotides, and various tools for molecular biology, APExBIO empowers researchers to achieve perfection and explore the unknown. Here are some highlights:
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EGFR probe for ISH CE/IVD - Brain and neural pathology
The receptor for epidermal growth factor (EGFR) also known as HER1 or ERBB1, is a transmembrane receptor tyrosine kinase of the ERBB family. This is a family of four receptors (ERBB1-4 or HER1-4) with EGFR the best characterized. EGFR is a prime target for cancer therapy across a broad variety of tumor types. Glioblastoma is the most common malignant brain tumor in adults, and among the most lethal of all cancers. Glioblastomas are divided into four subtypes: classical, proneural, mesenchymal and neural. EGFR amplification is enriched in the classical subtype. Amplification of the EGFR gene occurs in 57.4% of primary glioblastoma patients compared to 8% of secondary glioblastoma patients and is associated with high levels of EGFR protein. EGFR deletions in glioblastoma include EGFRvI (N-terminal deletion), vII (deletion of exons 14–15), vIII (deletion of exons 2–7), vIV (deletion of exons 25–27), vV (deletion of exons 25–28), among which vII and vIII are oncogenic.
Search result : 13 product found
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RUOCE / IVD
- Unconjugated 13
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- Inhibitor/Antagonist/Agonist 11
- Protein/peptide 2
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