
Anti-ACTH CE/IVD for IHC - Neuropathology
POMC (pro-opiomelanocortin), also known as corticotropin-lipotropin, is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific post-translational processing by prohormone convertases. POMC is cleaved into ten hormone chains named NPP, γ-MSH, ACTH, α-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin β, Lipotropin γ, β-MSH, β endorphin and Met-enkephalin.
Adrenocorticotropic Hormone (ACTH or corticotropin) is a peptidic hormone synthesized in cells of the anterior pituitary and in neurons in brain. It regulates the corticosteroid production in the adrenal cortex. The primary application of anti-ACTH is in the identification of pituitary tumours and the study of pituitary disease. The Anti-ACTH antibody reacts with ACTH-producing cells (corticotrophs). It may also cause paraneoplastic syndromes by secreting ACTH from other tumors (e.g., some small cell carcinomas of the lung).
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Pituitary gland section
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Description
Cond.
Price Bef. VAT
PDM583-S
2ml
PDM583
6ml
Mob244-05
0.5ml
Mob244
1ml
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