Neutral red assays

Neutral red assays

 

The utilization of Neutral Red Cell Proliferation and Cytotoxicology Assays represents a pivotal approach in cellular research, leveraging the intrinsic ability of cells to absorb neutral red for the nuanced assessment of cell proliferation and cytotoxicity. This methodology hinges on the dynamic interplay between living cells and neutral red, which is readily absorbed and accumulates within lysosomes. As cell proliferation intensifies, corresponding to an increase in cell numbers, the uptake of neutral red proportionally amplifies. Conversely, cellular damage disrupts the cells' ability to absorb neutral red, providing a discernible indicator of compromised cell integrity.

Beyond its role as a marker for cellular health, neutral red also serves as a versatile pH indicator. Under acidic conditions, it exhibits a distinctive red hue, transitioning to yellow as the pH elevates from 6.8 to 8.0. This unique attribute allows for the visualization and quantification of pH variations within cellular compartments. Notably, the acidic nature of the nucleus aligns with the yellow staining observed in this organelle when exposed to neutral red. Furthermore, the lysosomal environment, characterized by its acidic pH, manifests as a red stain upon interaction with neutral red.

The comprehensive understanding of these cellular responses is imperative for the accurate interpretation of cell proliferation dynamics and cytotoxic effects. Furthermore, the molecular characterization of neutral red, with a molecular formula of C15H17IN4 and a molecular weight of 288.8 kDa, enhances the precision and depth of our analytical toolkit. In this pursuit, the Neutral Red Cell Proliferation and Cytotoxicology Assays emerge as invaluable tools, offering a holistic perspective on cellular health, function, and response to external stimuli.

La compréhension globale de ces réponses cellulaires est impérative pour l'interprétation précise de la dynamique de la prolifération cellulaire et des effets cytotoxiques. En outre, la caractérisation moléculaire du rouge neutre, avec une formule moléculaire de C15H17IN4 et un poids moléculaire de 288,8 kDa, améliore la précision et la profondeur de notre boîte à outils analytique. Dans cette optique, les essais de prolifération cellulaire et de cytotoxicologie du rouge neutre se révèlent être des outils inestimables, offrant une perspective holistique de la santé et de la fonction cellulaires, ainsi que de la réponse aux stimuli externes.

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PL.8056/25
 4x250ml