Oncogene NGS panels

Oncogene NGS panels

The ONCOTARGET Kit is an NGS panel designed to identify, rapidly and reliably, genetic mutations associated with several cancer pathologies from patient samples of various types, thus guiding practitioners in their cancer treatment decisions. Thanks to its compact size and low sequencing depth (> 80X), this panel offers low-cost analysis.

ONCOTARGET is a combination of 1229 different probes, enabling the detection of mutations present on all the coding parts of 10 genes used to guide 1st and 2nd line therapy of several metastatic solid cancers.

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The ONCOTARGET panel has been developed and tested for its efficiency on all types of human samples:

  • DNA extracted from fresh, frozen or fixed paraffin-embedded tumors (FFPE).
  • DNA from liquid samples (plasma, pleural fluid, cerebrospinal fluid).
  • DNA extracted from human cell lines.

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Table: Details of genes analyzed 

 

Gene

Type of Tumor

Associated treatment  Impact
ALK Non small cell lung cancer ALK TKI Sensitivity of resistance to ALK inhibitor
BRAF Colon cancer No therapeutics MSI Testing
Non small cell lung cancer BRAF inhibitor Sensitivity only for the p.(Val600Glu) variant
Melanoma BRAF inhibitor Sensitivity only for p.(Val600X) variants
EGFR Non small cell lung cancer EGFR TKI Sensitivity or resistance (secondary mutations, insertions exon 20)
ERBB2 Non small cell lung cancer Mobocertinib Sensitivity
KIT GIST Imatinib Sensitivity or resistance (secondary mutations)
Melanoma Imatinib Sensitivity
KRAS Colon cancer EGFR inhibitor Resistance
Non small cell lung cancer Sotorasib Sensitivity only for p.(Gly12Cys).
MAP2K1 Melanoma BRAF inhibitor Resistance
  MEK inhibitor Sensitivity or resistance
MET Non small cell lung cancer MET TKI Sensitivity
NRAS Colon cancer EGFR inhibitor Resistance
Melanoma Prognosis /
PDGFRA GIST Imatinib Sensitivity or resistance (secondary mutations)

   GIST, gastrointestinal stromal tumor; MSI, microsatellite instability; TKI, tyrosine kinase inhibitor(s).

 

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Cat#
Description
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Price Bef. VAT
NB-62-0001-16
 16rxns 
NB-62-0001-32
 32rxns 
NB-62-0001-8
 8rxns 
NB-62-0001-96
 96rxns 
NB-62-0001-384
 384rxns