Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Anti-Granzyme B is useful for recognizing NK cell, anaplastic large cell, or T-cell lymphomas. Granzyme B is also present in Reed-Sternberg cells of Hodgkin's disease. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas in conjunction with CD56.