Reagents and instruments for immunology, cell biology and molecular biology.
 

Applied StemCell

Applied StemCell Inc. (ASC) is a fast growing biotechnology company with its headquarter based in Menlo Park, California.

With solid expertise and extensive experience in stem cell and transgene technologies, ASC focuses on the application of new technologies for stem cell and transgenic communities.

Based on Proprietary Technologies, Applied StemCell focus on development and commercialization of:

  • Stem Cell Culture Products
  • Stem Cell Lines and iPS Cell Generation Kits
  • Complete ES/iPS Cell Pluripotent Analysis (from Biomarker Kits to In Vivo Teratoma Formation Analysis)
  • ES Cell Karyotyping and Sex Determination Service
  • Knockout and Transgenic Services
  • Proprietary TARGATTTM Technology: Fast and Cost-effective Site-specific Transgenic Mouse Service
  • Proprietary TARGATTTM Technology: Gene Modification in Stem Cells
  • Proprietary TARGATTTM Technology: Generation of Humanized Animal Models
  • Proprietary TARGATTTM Technology: Generation of Stable Production CHO Cell Lines for High Expression of Proteins





Website: www.appliedstemcell.com

 
> Applied StemCell > Products for research > Biological Samples > Primary cells > Human primary cells > Human Primary cells - Cardiac system > Human Cardiomyocytes
Human Cardiomyocytes

Human Cardiomyocytes


Cardiac myocytes or cardiomyocytes are the most physically energetic cells in the body. They are highly specialized high-oxygen-content cells that house a large number of mitochondria. They occupy as much as 75% of the cardiac mass, but constitute only about one third of the total cell number in the heart. Differentiated cardiac myocytes have little capacity to proliferate; however, hypertrophic growth has been shown to respond to alpha1-adrenergic stimuli via the Ras/MEK pathway. All cardiac myocytes are capable of spontaneous rhythmic depolarization and repolarization of their membranes. Contraction of cardiac myocytes is myogenic, which is independent of nervous stimulation. There is a complex network of signals in cardiac myocytes regulating the rhythmic pumping of the heart. Cardiac myocyte hypertrophy and apoptosis have been implicated in the loss of contractile function during heart failure. A better understanding of the cardiac signaling network will help reveal the cellular mechanisms leading to cardiac myocyte death.

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