GLYcoDiag
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GLYcoDiag is a research and development company specialized in glycosciences which provides services and products for the fields of health (biomarkers, therapeutic recombinant glycoproteins, vaccines), cosmetics (active ingredients, design and mechanisms of “glyco-actives”) and environment (biofilms, waste water).
Since 2015, GLYcoDiag develop its own range of reagents and kits for research uses:
Natural and recombinant lectins
Neoglycoproteins and neoglycoclusters
LEctPROFILE® gels, CarbPROFILE gels LEctPROFILE® kits (lectin based kits intended for ligands screening / comparison / detection) Website : www.glycodiag.com
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![Agaricus bisporus (Mushroom) Lectin (ABA/ABL)](https://www.clinisciences.com/en/upload/thumbs/agaricus-bisporus-mushroom-lectin-myub3n-5d6ae1.jpg)
Agaricus bisporus (Mushroom) Lectin (ABA/ABL)
Agaricus bisporus agglutinin / lectin (ABA / ABL) is a mixture of two phytohemagglutinins with similar specificities for carbohydrate receptors (PHA-A and PHA-B). Both PHA-A and PHA-B are heterogeneous by SDS-PAGE. The mushroom PHA will have a molecular weight of 58.5 kDa as determined by gel filtration that corresponds to tetramer. Each monomer has 2 distinct carbohydrate binding sites, one for galactose-β-1,3-N-acetylgalactosamine (also called Thomsen-Friedenreich antigen or T disaccharide) and another for galactose-β-1,3-N-acetylglucosamine.
ABA has a non-specific blood group since PHA-A and PHA-B agglutinate erythrocytes independent of their blood group type. Agaricus bisporus has an anti-proliferative effect on cancerous cells. ABA can be internalized by clathrin-coated vesicles after binding to surface glycoproteins.
Agaricus bisporus agglutinin (ABA) inhibits proliferation of malignant cells without cytotoxicity for normal cells.
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